患者男,67岁,主因排尿不畅半年,加重伴尿频、尿急、尿痛4日入院。入院诊断:1.前列腺增生;2.下泌尿道感染。既往无药物及其他过敏史。体检:一般状况良好,心、肺、腹未见明显异常。入院后给予甲磺酸培氟沙星注射液O.4g静滴,qd(晨9:00),患者于当晚23:00出现喉头肿胀,疼痛,伴瘙痒及窒息感,急予苯海拉明20mg im,地塞米松10mg iv后,症状缓解并逐渐消失,水肿消退。次日晨,再次给予甲磺酸培氟沙星注射液O.4g静滴,患者于当晚21:00再次出现相同症 Male patient, 67 years old, mainly due to poor urination six months, increased with frequent urination, urgency, dysuria 4 admitted to hospital. Admission diagnosis: 1. Prostatic hyperplasia; 2. Lower urinary tract infection. No past history of drugs and other allergies. Physical examination: generally good, heart, lung, abdomen no obvious abnormalities. After admission, pefloxacin mesylate injection O.4g intravenous infusion, qd (morning 9:00), the patient appeared in the evening 23:00 laryngeal swelling, pain, itching and asphyxia, acute diphenhydramine 20mg im, dexamethasone 10mg iv, the symptoms ease and gradually disappear, edema subsided. The next morning, once again given pefloxacin mesylate injection O.4g intravenous infusion, the patient again the same night at 21:00