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目的 :评价丽珠肠乐治疗慢传输性便秘的疗效。方法 :采用随机对照试验方法 ,选择慢传输性便秘 76例 ,随机分为治疗组 (39例 )和对照组 (37例 ) ,分别接受丽珠肠乐和乳果糖治疗 ,疗程 4周。观察排便次数、第 1次排便时间和排便困难变化及结肠转运时间 ,疗效评估采用模拟视觉梯度的评分方法 (10 0 m m VAS)。结果 :多数患者服药 1d即出现排便 ,治疗组和对照组分别为 6 5 .7%和 6 7.2 %。每周排便次数分别从治疗前的 (2 .1± 0 .1)次和 (2 .3± 0 .1)次增加至治疗 4周后的 (7.4± 0 .4 )次和 (7.3± 0 .5 )次 (P<0 .0 5 ) ,两组间差异无显著性意义 (P>0 .0 5 )。治疗 4周后 ,两组排便困难改善 ,分别从治疗前的 86 .5 %和 89.6 %下降至治疗后的 32 .4 %和 35 .1% (P <0 .0 5 )。治疗组 10 0 mm VAS评分为 72 .3,显著高于对照组的 5 4 .2 (P <0 .0 5 )。结肠转运时间治疗组和对照组分别从治疗前的 (82 .1± 3.5 ) h和 (79.6± 2 .9) h缩短至 (5 6 .3± 4 .2 ) h和 (5 2 .4± 2 .8) h(P <0 .0 5 )。结论 :丽珠肠乐治疗慢传输性便秘安全有效。
Objective: To evaluate the efficacy of Lizhu Gengle in treating slow-transit constipation. Methods: A randomized controlled trial was conducted in which 76 patients with slow-transit constipation were randomly divided into treatment group (n = 39) and control group (n = 37). Lactucae and lactulose were administered respectively for 4 weeks. The defecation frequency, defecation time, defecation difficulty and colonic transit time were observed. The curative effect was evaluated by simulated visual gradient (10 0 m V VAS). Results: Most patients showed defecation 1 day after taking the drug. The treatment group and the control group were 65.7% and 62.2% respectively. The number of bowel movements per week increased from (2.1 ± 0.1) and (2.3 ± 0.1) times before treatment to (7.4 ± 0.4) and (7.3 ± 0) after 4 weeks of treatment .5) times (P <0.05), there was no significant difference between the two groups (P> 0.05). After 4 weeks of treatment, the defecation difficulties improved in both groups from 86.5% and 89.6% before treatment to 32.4% and 35.1% (P <0.05) after treatment, respectively. The VAS score of 10 mm in the treatment group was 72.3, which was significantly higher than that of the control group (P <0.05). Colonic transit time in treatment group and control group decreased from (82.1 ± 3.5) h and (79.6 ± 2.9) h to (56.3 ± 4.2) h and (52.4 ± 2 .8) h (P <0. 05). Conclusions: LZR is safe and effective in treating slow transit constipation.