分析动脉粥样硬化发生原因,Ross和Glomset(Science,180:1332,1973)提出:在动脉内膜的内皮和微孔性内弹力层之间平滑肌细胞的堆积表示损害的开始。幼年时,该处的肌细胞罕见,但随着年岁长大其数目乃增多,从而使内膜增厚。作者主张,内膜平滑肌细胞增多伴有细胞内外脂质沉积和结缔组织增加,就形成动脉粥样硬化。 To analyze the causes of atherosclerosis, Ross and Glomset (Science, 180: 1332, 1973) suggest that the accumulation of smooth muscle cells between the endothelium of the arterial intima and the microporous endometriotic layer signifies the onset of damage. Muscle cells are rare in infancy, but their number increases with age and thickens the intima. The authors assert that atherosclerosis develops as a result of increased intimal smooth muscle cells accompanied by increased lipid deposition inside and outside the cell and increased connective tissue.