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目的:观察超声雾化吸入利巴韦林联合盐酸氨溴索治疗小儿病毒性肺炎的疗效。方法:选取2009年6月至2010年6月浦江县人民医院儿科收治的小儿病毒性肺炎患者86例,随机分为两组,静脉滴注组40例给予利巴韦林10mg/(kg.d)+盐酸氨溴索7.5 mg+生理盐水200 mL静脉滴注治疗,每日2次;雾化吸入组46例,应用利巴韦林注射液10 mg/(kg.d)+盐酸氨溴索7.5 mg+生理盐水20mL超声雾化吸入,每日2次。治疗7d后,统计疗效并比较两组患者症状、体征改善时间。结果:超声雾化组的总有效率为91.3%,而静脉滴注组的总有效率为72.5%,两组疗效比较差异有统计学意义(P<0.05)。超声雾化组患者的症状、体征改善时间比静脉滴注组明显缩短(P<0.05)。结论:超声雾化吸入治疗小儿病毒性肺炎疗效确切,无明显不良反应,且具有操作简便,患者容易接受的优点。
Objective: To observe the effect of inhalation of ribavirin combined with ambroxol hydrochloride on children with viral pneumonia by ultrasonic atomization. Methods: Totally 86 pediatric patients with viral pneumonia admitted from Pujiang County People’s Hospital from June 2009 to June 2010 were randomly divided into two groups: 40 patients in the intravenous drip group received ribavirin 10mg / (kg.d ) + Ambroxol hydrochloride 7.5 mg + saline 200 mL intravenously, twice a day; aerosol inhalation group 46 cases, the application of ribavirin injection 10 mg / (kg.d) + ambroxol hydrochloride 7.5 mg + saline 20mL ultrasonic inhalation, 2 times a day. After 7 days of treatment, the curative effect was compared and the symptoms and signs of two groups were compared to improve the time. Results: The total effective rate of ultrasonic atomization group was 91.3%, while the total effective rate of intravenous drip group was 72.5%. The difference between the two groups was statistically significant (P <0.05). The symptoms and signs of patients in the ultrasonic atomization group were significantly shorter than those in the intravenous drip group (P <0.05). Conclusion: The treatment of infantile viral pneumonia by ultrasonic nebulization is effective and has no obvious adverse reactions. It has the advantages of easy operation and patient acceptance.