以脊髓灰质炎病毒为代表的小核糖核酸类病毒,是当前发展重组活疫苗的一组重要载体。由于其遗传背景清楚,操作方便且高效和多价性,一直为世人所关注。目前此类载体已从最早的适应嵌合病毒技术开始发展到了今天能适应杂交病毒复制子、杂交病毒等新技术,并且逐步从实验阶段走向了实用阶段。可以相信,随着这些技术的不断完善和发展,小核糖核酸类病毒必将为人类提供新一代的活疫苗载体。 The picornavirus, represented by poliovirus, is a group of important vectors for the current development of recombinant live vaccines. Due to its clear genetic background, easy operation and high efficiency and multivalent, it has been the world’s attention. At present, such vectors have been developed from the earliest adaptation to chimeric virus technology to today’s new technologies such as hybrid virus replicons and hybrid viruses, and gradually moved from the experimental stage to the practical stage. It is believed that with the constant improvement and development of these technologies, Picornavirus is bound to provide a new generation of live vaccine vectors for human beings.