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目的调查分析与儿童重症结核病相关的危险因素。方法回顾性研究2002年1月至2010年12月北京儿童医院住院病人中诊断为结核病的0～17岁儿童结核病病例,并对可能影响儿童患重症结核病的危险因素进行单因素及多因素的logistic回归分析。结果年龄、卡介苗接种、结核病接触史及PPD试验4项研究因素P值小于0.05,OR值及95%可信区间分别为:0.716(0.650～0.789),0.606(0.468～0.784),1.483(1.131～1.945)和0.417(0.317～0.549)。结论小于1岁、未接种卡介苗、有结核病密切接触史及PPD试验结果阴性是儿童重症结核病的独立危险因素。
Objective To investigate and analyze the risk factors related to severe tuberculosis in children. Methods A retrospective study was conducted on the tuberculosis cases among 0-17-year-old children diagnosed as tuberculosis in Beijing Children’s Hospital from January 2002 to December 2010 and the univariate and multivariate logistic regression analyzes were performed on the risk factors that may affect the children with severe tuberculosis. regression analysis. Results There were no significant differences among the four study factors in age, BCG vaccination, history of exposure to tuberculosis and PPD test. The P values were less than 0.05 and the OR and 95% confidence intervals were 0.716 (0.650-0.889), 0.606 (0.468-0.784), 1.483 1.945) and 0.417 (0.317 ~ 0.549). Conclusions Children younger than 1 year old, non-vaccinated BCG, history of close contact with tuberculosis and negative PPD test are independent risk factors for severe tuberculosis in children.