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机体在应激状态下血浆血管紧张素Ⅱ（ＡⅡ）和心房肽（ＡＮＰ）浓度均显著升高，同时免疫功能亦有明显改变。本文采用免疫学方法检测了应激激素ＡⅡ和ＡＮＰ对小鼠细胞免疫功能的影响。结果表明：（１）ＡⅡ（１０－１２～１０－１０ｍｏｌ／Ｌ）在体外明显抑制脾细胞对分裂原（刀豆蛋白Ａ，ＣｏｎＡ）的增殖反应及白细胞介素２（ＩＬ２）的产生，而ＡＮＰ（１０－１２～１０－１０ｍｏｌ／Ｌ）可协同ＣｏｎＡ促进脾细胞增殖和ＩＬ２产生。（２）ＡⅡ可显著促进巨噬细胞（Ｍ）的吞噬功能，而ＡＮＰ则起抑制作用。提示：ＡⅡ和ＡＮＰ对细胞免疫功能有显著影响，且二者的作用表现出相互制约、相互平衡。
The body’s plasma angiotensin Ⅱ (AⅡ) and atrial natriuretic peptide (ANP) concentrations were significantly increased under stress, meanwhile the immune function also changed obviously. In this paper, immunological methods were used to detect the impact of stress hormone A Ⅱ and ANP on cellular immune function. The results showed that: (1) AII (10-12-10-10 mol / L) significantly inhibited the proliferation of splenocytes (ConA) and the production of interleukin-2 (IL-2) , While ANP (10-12 ~ 10-10mol / L) can be combined with ConA to promote spleen cell proliferation and IL 2 production. (2) AⅡ can significantly promote phagocytosis of macrophages (M), while ANP can inhibit the phagocytosis of macrophages (M). Tip: A Ⅱ and ANP have a significant effect on cellular immune function, and the role of the two showed mutual restraint and balance.