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目的:探讨染色体核型异常与生育异常的关系。方法:对2004年5月～2008年5月到吉林省生殖医学研究所临床基地进行遗传咨询的2 485例患者进行外周血淋巴细胞培养和染色体核型分析。结果:2 485例患者中,染色体核型异常患者257例,异常率为10.34%。在染色体异常核型中,性染色体异常154例,占59.92%;常染色体异常103例,占40.08%。结论:生育异常与染色体核型异常有着密切的关系,对生育异常患者进行染色体核型分析,有利于临床诊断,也可为遗传咨询提供依据。
Objective: To investigate the relationship between chromosomal abnormalities and fertility abnormalities. Methods: Peripheral blood lymphocytes and chromosome karyotypes were analyzed in 2 485 patients with genetic counseling from May 2004 to May 2008 at the clinic of Jilin Reproductive Medicine Institute. Results: Of the 2 485 patients, 257 were abnormal in karyotype, with an abnormal rate of 10.34%. In chromosomal abnormal karyotypes, 154 cases of chromosomal abnormalities, accounting for 59.92%; autosomal abnormalities in 103 cases, accounting for 40.08%. Conclusion: There is a close relationship between abnormal fertility and chromosomal abnormalities in karyotypes. Chromosomal karyotyping in patients with abnormal fertility is helpful for clinical diagnosis and genetic counseling.