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目的观察钙粒蛋白(S 1 00A 9)在胃癌组织中的表达,探讨其临床意义。方法随机选取2 01 2年1月-2 01 4年6月东莞市第五人民医院胃癌手术切除患者的60例胃癌组织标本作为胃癌组,60例癌旁正常组织标本作为对照组。采用免疫组化方法比较两组组织标本中S 1 00A 9的表达,探究S 1 00A 9的表达与患者胃癌TNM分期及癌细胞分化程度的关系。结果胃癌组S 1 00A 9阳性者有4 1例(阳性率为68.3 3%),高于对照组的1 1例(阳性率为1 8.3 3%),差异有统计学意义(P<0.05);胃癌组中,患者的胃癌TNM分期Ⅲ期及以上者S 1 00A 9阳性率为93.1 0%,高于Ⅰ期和Ⅱ期的64.52%,癌细胞低分化者S 1 00A 9阳性率为80.76%,高于中、高分化者的58.82%,差异均有统计学意义(P<0.05)。结论 S 1 00A 9在胃癌组织中的表达较高,且与胃癌的进展呈正相关,与癌细胞的分化程度呈负相关。
Objective To investigate the expression of calcitonin (S 1 00A 9) in gastric carcinoma and to explore its clinical significance. Methods Sixty gastric cancer specimens from patients undergone gastric resection in the Fifth People’s Hospital of Dongguan City from January 2001 to January 2004 were randomly selected as the gastric cancer group and 60 adjacent normal tissues as the control group. Immunohistochemistry was used to compare the expression of S 1 00A 9 in two groups of tissues to explore the relationship between the expression of S 1 00A 9 and the TNM staging of gastric cancer and the differentiation of cancer cells. Results There were 41 cases of S 1 00A 9 positive in gastric cancer group (positive rate was 68.3 3%), which was higher than that in control group (1 8.33%) (P <0.05) . In the gastric cancer group, the positive rate of S 1 00A 9 in patients with stage Ⅲ or higher TNM stage Ⅲ gastric cancer was 93.1 0%, which was higher than 64.52% in stages Ⅰ and Ⅱ, and the positive rate of S 1 00A 9 in poorly differentiated cancer cells was 80.76 %, Higher than 58.82% of the well-differentiated, the difference was statistically significant (P <0.05). Conclusion S 1 00A 9 is highly expressed in gastric cancer tissues and positively correlated with the progression of gastric cancer and negatively correlated with the differentiation of cancer cells.