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采用ＳＤ 大鼠离体气管，与重金属解毒药二巯基丁二酸（ ＤＭＳＡ） 对照，观察了解毒健脾中药提取物０２ 号（ 中药０２ 号） 对呼吸道平滑肌镉染毒的保护作用。结果显示：（１） 镉对气管平滑肌的抑制作用在一定范围内呈浓度依赖性。当氯化镉浓度为６ ｍ ｍｏｌ／Ｌ，９ ｍ ｍ ｏｌ／Ｌ 时，气管平滑肌对乙酰胆碱的最大收缩效应（Ｅｍａｘ） 从９８ ±３（ ｎ ＝ ６） 分别降至５３ ±２８（ ｎ ＝ ７ ，Ｐ＜ ０－０５） 、１９ ±１５（ ｎ ＝ ７ ，Ｐ＜ ０－００１ ；（２） 当用中药０２ 号预处理气管后，氯化镉的抑制作用减弱，Ｅｍａｘ 从１９ ±１５ 恢复至６２ ±２７（ ｎ ＝ ５ ，Ｐ＜ ０－０５） 和５６ ±２８（ ｎ ＝ ５ ，Ｐ＜ ０－０５） 与用ＤＭＳＡ 后（Ｅｍ ａｘ 恢复至４０ ±１０ 和７０ ±１０） 比较，两者间无显著性差异（ Ｐ＞ ０－０５） 。氯化镉对气管平滑肌收缩的抑制作用，可能与其影响乙酰胆碱对Ｍ 受体的亲和力和（ 或） 抑制钙通道有关；中药０２ 号的作用，可能与ＤＭＳＡ 的解毒机理相同，即与氯化镉形成络合物，而发挥预防作用。亦说明用中药预防或治疗镉中毒是一条新的途径
The isolated rat trachea of SD rats was used to compare with the heavy metal antidote dimercaptosuccinic acid (DMSA) to observe the protective effect of poisonous and spleen Chinese herbal extract No. 02 (TCM 02) on the cadmium exposure of airway smooth muscle. The results showed that: (1) The inhibitory effect of cadmium on tracheal smooth muscle was concentration-dependent in a certain range. When the concentration of cadmium chloride was 6 m mol/L and 9 mmol/L, the maximum contraction effect (Emax) of acetylcholine on tracheal smooth muscle was reduced from 98 ± 3 (n = 6) to 53 ± 28 (n = 7). P<0-05), 19 ±15 (n = 7 , P< 0-001; (2) When the trachea was pretreated with Chinese Herb No. 02, the inhibition of cadmium chloride was weakened and Emax recovered from 19 ± 15 62 ±27 (n = 5, P<0-05) and 56 ±28 (n = 5, P<0-05) compared with DMSA (Em ax recovery to 40 ±10 and 70 ±10), both There was no significant difference between the two groups (P> 0-05).The inhibitory effect of cadmium chloride on the contraction of tracheal smooth muscle may be related to its effect on the affinity of acetylcholine to M receptor and (or) calcium channel inhibition; Similar to the detoxification mechanism of DMSA, that is, it forms a complex with cadmium chloride and plays a preventive role. Medicine is a new way to prevent or treat cadmium poisoning