抗核抗体(antinuclear antibody,ANA)是一种自身抗体,为自身免疫反应和某些自身免疫性疾病的产物。其致病机理一般认为是由于各种细胞核抗原,引起了自身抗体的产生,循环中的抗体与暴露的胞核起反应,形成大量免疫复合物,当其沉着在小动脉壁上引起血管炎。特别是沉着在肾小球的基底膜与内皮细胞之间,引起肾小球病变以及其他免疫病理损伤。 Antinuclear antibody (ANA) is an autoantibody that is a product of the autoimmune response and certain autoimmune diseases. Its pathogenic mechanism is generally believed to be due to a variety of nuclear antigens, causing the production of autoantibodies, circulating antibodies react with the exposed nucleus, forming a large number of immune complexes, when it calm in the arteriole wall cause vasculitis. Especially in the glomerular basement membrane and endothelial cells, causing glomerular lesions and other immunopathological damage.