TTM-2结果公布,复苏后目标温度如何选择

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目标温度管理(target temperature management, TTM)应用于临床已经有20年的历史,是目前唯一被指南推荐用于心脏骤停患者脑保护的干预措施,但是关于最佳目标温度,仍然存在很多争议。2021年6月,TTM-2研究结果公布,该研究是目前关于心脏骤停样本量最大的RCT研究,共入选1 850例院外心脏骤停患者(out of hospital cardiac arrest, OHCA)患者,随机分为低温组(目标温度33 ℃)和常温组(体温>37.8 ℃时积极处理发热),结果发现与常温相比,33 ℃-TTM并不能进一步降低6个月的病死率和不良神经结局的比例n [1]。TTM-2结果公布,可能会对指南和临床实践产生新的影响,但是错误的解读可能会带来不良后果。n
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