核素心肌显像是诊断冠心病的重要手段。过去最常用的心肌显像剂~(201)T1的价格极贵,自1984年Pen-deletow首次采用~(99m)Tc标记的异腈化合物进行心肌显像的动物实验后,1986年国外又报道了新的异腈化合物——2-甲基-2-异氰基丙酸甲酯(carbomethoxyisopropyl isonitrile,简称CPI),其心肌摄取率较高,而肺和肝的摄取率均较低,是一种很有前途的心肌显像剂。作者合成了CPI,并对其在动物体内的分布和心肌显像进行了初步研究。 Radionuclide myocardial imaging is an important means of diagnosis of coronary heart disease. In the past, the most commonly used myocardial imaging agent ~ (201) T1 was extremely expensive. Since 1984, Pen-deletow’s first animal experiment of myocardial imaging with ~ (99m) Tc labeled isonitrile compounds was reported abroad in 1986 A new isonitrile compound, carbomethoxyisopropyl isonitrile (CPI), has a high myocardial uptake rate and a low uptake rate of lung and liver, which is one A very promising myocardial imaging agent. The authors synthesized the CPI and conducted a preliminary study of its distribution in animals and myocardial imaging.