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患有髓母细胞瘤的儿童在接受全脑全脊髓放疗(ＣＳＩ)后易发生内分泌功能障碍。虽然生长激素分泌不足最常见 ,但直接照射甲状腺 (原发性 )或照射下丘脑 垂体轴 (中枢性 )都可能引起甲状腺功能减低。为分析比较低剂量全脑全脊髓照射 (2 3.4Ｇｙ)合并化疗与标准剂量 (36Ｇｙ)照射
Children with medulloblastoma develop endocrine dysfunction after receiving whole-brain total radiotherapy (CSI). Although under-secretion of growth hormone is the most common, direct thyroid (primary) or hypothalamic pituitary (central) irradiation may cause hypothyroidism. To analyze and compare low-dose whole-brain whole-spinal irradiation (2 3.4Gy) combined with chemotherapy and standard dose (36Gy) irradiation