【摘 要】
：
妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的最大危害是导致围生儿结局不良[1]:早产(19%～60%)、羊水胎粪污染(27%)、胎儿心动过缓(14%)、胎儿窘迫(22
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妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的最大危害是导致围生儿结局不良[1]:早产(19%～60%)、羊水胎粪污染(27%)、胎儿心动过缓(14%)、胎儿窘迫(22%~41%)、胎儿死亡(0.4%~4.1%).但是引起ICP的病因及发病机制至今尚未确定,较为公认的观点是,ICP是一种多病因疾病,激素、遗传变异等均对ICP的发病起一定的作用,而ICP发生围生儿缺氧可能是一个多因素的过程.现就近年来有关研究现状综述如下.
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