建立ＥＡＥ动物模型，检测脾细胞培养上清中γ干扰素（ＩＦＮγ）及白细胞介素４（ＩＬ４）水平。结果显示，实验性变态反应性脑脊髓炎（ＥＡＥ）组ＩＦＮγ浓度高于对照组（Ｐ＜０．０５），而ＩＬ４浓度低于对照组（Ｐ＜０．０１）。表明ＩＦＮγ和ＩＬ４参与ＥＡＥ的发病 Animal model of EAE was established to detect the levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in the spleen cell culture supernatant. The results showed that IFNγ concentration in experimental allergic encephalomyelitis (EAE) group was higher than that in control group (P <0.05), while IL4 concentration was lower than that in control group (P <0.01). That IFN  γ and IL  4 involved in the pathogenesis of EAE