近年来从海洋中获取生物药品逐渐增多,但迄至1971年,临床上还没有找到一种有效的抗肿瘤药,只有阿糖胞苷是根据海绵的抗肿瘤活性物质研究而合成。其他多半是粗提取物,但未经标准的肿瘤试验方法筛选以比较其抗癌效果,其中有些虽对动物肉瘤180有效而对L1210白血病无效;有些理化性质尚未完全阐明,关于作用机理更少报道。 In recent years, there has been a gradual increase in access to biological medicines from the sea. However, as of 1971, no effective anti-tumor drug has been clinically found. Only cytarabine is synthesized based on the study of sponge anti-tumor active substances. Others are mostly crude extracts that have not been screened for their anticancer efficacy by standard oncology assays, some of which are ineffective against L1210 leukemia, although effective against animal sarcoma 180; some of the physico-chemical properties have not been fully elucidated and are less reported on the mechanism of action .