帕金森病(Parkinson’s disease,PD)是一种进行性神经退行性疾病。资料显示,有10万加拿大人和0.3%的美国人患有 PD。在我国,PD 的发病率为15/10万～119/10万。PD 临床症状以震颤、肌僵直、运动减少及姿势调节障碍为主要特征。但近年来发现,PD 患者有逐渐进展的记忆功能下降。测试发现,约有50%的早期 PD 患者有轻度认知障碍。随着病程的发展,约30%的 PD 患者后期有痴呆。研究表明,在年龄>70岁的 PD 患者中,痴呆发病率为69%,是50～59岁 PD 患者(12%)的5倍。经过治疗,PD 患者 Parkinson’s disease (PD) is a progressive neurodegenerative disease. Data show that 100,000 Canadians and 0.3% of Americans have PD. In our country, the incidence of PD is 15/10 to 119/10 million. The clinical features of PD are characterized by tremors, muscle rigidity, decreased motion and posture adjustment disorders. However, in recent years, it has been found that PD patients have a progressive decline in memory function. The test found that about 50% of early PD patients have mild cognitive impairment. With the development of the course of disease, about 30% of PD patients have dementia late. Studies have shown that the incidence of dementia is 69% in PD patients> 70 years of age, which is five times greater than those in PD patients 50 to 59 years old (12%). After treatment, PD patients