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目的:探讨急性心肌梗死行经皮冠状动脉介入治疗(PCI)血清炎症因子的改变及其与预后的关系。方法:选择126例拟行PCI治疗的急性心肌梗死患者为研究对象,比较PCI手术前后血清超敏C反应蛋白(hs-CRP)及肿瘤坏死因子α(TNF-α)的改变。同时比较PCI术后3月发生心血管事件患者与未发生心血管事件患者术后12h血清hs-CRP及TNF-α的差别。结果:患者PCI术后血清hs-CRP及TNF-α水平均显著升高,与术前相比差别具有统计学意义(P<0.05);PCI术后3月发生心血管事件患者PCI术后12h血清hs-CRP及TNF-α水平显著高于未发生心血管事件患者(P<0.05);Logistic回归结果显示:hs-CRP及TNF-α与心血管事件发生率显著相关。结论:急性心肌梗死行PCI患者术后发生急性炎症反应,hs-CRP及TNF-α水平升高与患者心血管事件发生密切相关,可作为评估预后的血清学指标。
Objective: To investigate the changes of serum inflammatory factors in patients with acute myocardial infarction undergoing percutaneous coronary intervention (PCI) and its relationship with prognosis. Methods: A total of 126 patients with acute myocardial infarction undergoing PCI were enrolled in this study. The changes of serum hs-CRP and TNF-α before and after PCI were compared. The differences of serum hs-CRP and TNF-α between the patients with cardiovascular events and the patients without cardiovascular events at 12 h after PCI were compared. Results: The serum levels of hs-CRP and TNF-α in patients after PCI were significantly higher than those before operation (P <0.05). The incidence of cardiovascular events in patients after PCI at 12 months The serum levels of hs-CRP and TNF-α were significantly higher than those without cardiovascular events (P <0.05). Logistic regression analysis showed that there was a significant correlation between hs-CRP and TNF-α and the incidence of cardiovascular events. Conclusions: The acute inflammatory response occurs after PCI in patients with acute myocardial infarction. Elevated hs-CRP and TNF-α levels are closely related to cardiovascular events and can be used as a serological marker to evaluate prognosis.