Objectives: The aims of this study were to describe the quality of life in pa tients with multiple sclerosis (MS) given immunological treatment and in those n ot given immunological treatment and to investigate the relationship between imp airment and quality of life. Methods: Twenty nine patients given immunological t reatment were matched with the same number of patients not given such treatment. Matching variables were sex, Kurtzke’s Expanded Disability Status Scale (EDSS ), years since diagnosis, and age (total n = 58). The patients were interviewed using the self-reported impairment checklist and they answered two questionnai res on quality of life, the 36-Item Short-Form Health Survey (SF-36) and t he Subjective -Estimation of Quality of Life (SQoL). Results: The self-repor ted impairment checklist captured a more differentiated picture of the patients ’ symptoms of MS than the EDSS. Health related quality of life was markedly re duced, while the subjective quality of life was less affected. There was a stron ger association between self-reported ratings of impairment and health related quality of life on the SF-36 than between impairment and global ratings of qu ality of life on the SQoL. Subjective quality of life on the SQoL was not direct ly dependent on impairment expressed in physical limitations. There were no stat istically significant differences between the treated and untreated groups. A no n-significant trend towards better health related quality of life was found in favour of the treated group with respect to emotional role, physical role, and social function on the SF-36. Conclusions: The self-reported impairment chec klist and SF-36 proved to be valuable complements to the well established EDSS in describing the diverse symptoms of MS. Measuring both health related quality of life and subjective wellbeing provides valuable knowledge about the conseque nces of MS. Objectives: The aims of this study were to describe the quality of life in pa tients with multiple sclerosis (MS) given immunological treatment and in those n ot given immunological treatment and to investigate the relationship between imp airment and quality of life. Methods: Twenty nine patients given immunological t reatment were matched with the same number of patients not given such treatment. Matching variables were sex, Kurtzke’s Expanded Disability Status Scale (EDSS), years since diagnosis, and age (total n = 58). The patients were interviewed using the self-reported impairment checklist and they were asked two questionnai res on quality of life, the 36-Item Short-Form Health Survey (SF-36) and t he Subjective-Estimation of Quality of Life (SQoL). Results: The self -repor ted impairment checklist captured a more differentiated picture of the patients’ symptoms of MS than the EDSS. Health related quality of life was markedly re duced, while the subjective quality of life was le ss affected. There was a stron ger association between self-reported ratings of impairment and health related quality of life on the SF-36 than between impairment and global ratings of qu ality of life on the SQoL. Subjective quality of life on the SQoL was not direct ly dependent on impairment expressed in physical limitations. There were no stat istically significant differences between the treated and untreated groups. A no n-significant trend to better health related quality of life was found in favor of the treated group with respect to emotional Role, physical role, and social function on the SF-36. Conclusions: The self-reported impairment chec klist and SF-36 proved to be valuable complements to the well established EDSS in describing the diverse symptoms of MS. of life and subjective wellbeing provides valuable knowledge about the conseque nces of MS.