三尖杉碱是抗癌药物——三尖杉酯类化合物的母体。它的全合成研究一直受到众多学者的亲睐。近几年来,取得了三条新的合成路线。共同特点是:采用单环或二环小分子为原料,巧妙地合成了具有独特五环结构的三尖杉硷(1)。其中的 Kuehne 路线,产率达到41%。 Celecoxib is an anticancer drug - the parent of the taxol compounds. Its total synthesis research has been favored by many scholars. In recent years, three new synthetic routes have been achieved. Common features are: the use of monocyclic or bicyclic small molecule as a raw material, cleverly synthesized has a unique pentacyclic structure of cephalomannine (1). One of the Kuehne routes, the yield reached 41%.