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目的探讨运城市男男性行为人群(MSM)艾滋病(AIDS)病人抗病毒治疗的效果,为进一步开展有效的抗病毒治疗提供依据。方法收集2010年1月至2013年6月运城市,MSM艾滋病病人抗病毒治疗的相关资料,分析病人的基本情况、治疗方案、治疗前后CD+4T淋巴细胞计数、病毒载量、机会性感染、不良反应、终止治疗及耐药状况。结果 55例MSM AIDS病人,年龄22~54岁,未婚占36.36%(20/55),已婚或同居占56.36%(31/55),离异或分居占7.27%(4/55);有肛交史的100%(55/55),有口交史的69.09%(38/55),有多性伴的96.36%(53/55),有固定性伴的3.64%(2/55)。在抗病毒治疗1/2年、1年、2年、3年,CD+4T淋巴细胞中位数由238/μL、224/μL、222/μL、75/μL增至292/μL、339/μL、423/μL、211/μL;抗病毒治疗3-36个月(平均13.81个月),88.89%(32/36)的病人病毒载量<40拷贝/mL;有机会性感染的AIDS病人数,由治疗前的40.00%(22/55)下降到抗病毒治疗6个月内的14.55%(8/55);43.64%(24/55)的病人出现不良反应;80.00%(44/55)的病人依从性≥95%;自行停药3.64%(2/55),死亡9.09%(5/55),失访3.64%(2/55),耐药16.67%(1/6)。结论运城市MSM AIDS病人存在特殊的性行为、多性伴等高危行为,服药依从性较好,抗病毒治疗效果显著。
Objective To explore the effect of anti-virus therapy on HIV-positive patients with MSM in Yuncheng and to provide basis for further effective anti-virus therapy. Methods The data of antiviral treatment of AIDS patients in Yuncheng City from January 2010 to June 2013 were collected. The basic information of the patients, the treatment plan, CD + 4T lymphocyte count, viral load, opportunistic infections, Adverse reactions, termination of treatment and drug resistance. Results 55 MSM AIDS patients aged 22-54 years old, 36.36% (20/55) were unmarried, 56.36% (31/55) married or cohabiting, and 7.27% (4/55) divorced or separated; had anal intercourse History of 100% (55/55), 69.09% (38/55) with oral history, 96.36% (53/55) with multiple partners, and 3.64% (2/55) of fixed partners. The median number of CD + 4T lymphocytes increased from 238 / μL, 224 / μL, 222 / μL, 75 / μL to 292 / μL at 1, 2, μL, 423 / μL, 211 / μL; antiviral therapy 3-36 months (mean 13.81 months), 88.89% (32/36) of patients with viral load <40 copies / mL; opportunistic infections of AIDS The number of patients decreased from 40.00% (22/55) before treatment to 14.55% (8/55) within 6 months after antiretroviral treatment; 43.64% (24/55) patients had adverse reactions; 80.00% (44/55) ) Patients were 95% (2/55), 9.09% (5/55) died, 3.64% (2/55) were lost to follow-up, and 16.67% (1/6) were resistant to drug. Conclusions Yuncheng MSM AIDS patients have special behaviors such as sexual behavior, multi-sexual partners and other high-risk behaviors. The medication compliance is good and the effect of antiviral therapy is significant.