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目的探讨冷冻胚胎复苏移植后的妊娠结局。方法2003年1月至2007年5月,对2～4细胞期胚胎进行慢速冷冻保存,快速复苏及移植,共有88例患者在哈尔滨医科大学第一临床医学院进行了120个周期的冷冻胚胎复苏移植,观察冷冻复苏移植的效果。结果复苏胚胎370个,存活316个,完整存活胚胎232个,移植316个胚胎,临床妊娠39例,妊娠率为32.5%(39/120)。胚胎种植率16.5%(52/316)。比较妊娠组与非妊娠组在年龄、雌二醇水平、子宫内膜厚度、胚胎复苏存活率及完整存活率上差异均无显著性意义(P>0.05),优质胚胎率差异有极显著性意义(P<0.01)。结论优质胚胎是移植后获得妊娠的关键,采用冻融胚胎移植技术可以提高辅助生殖技术的累计妊娠率。
Objective To investigate the pregnancy outcome after frozen embryo resuscitation and transplantation. METHODS: From January 2003 to May 2007, 2 to 4-cell embryos were cryopreserved, rapidly resuscitated and transplanted. A total of 88 patients underwent 120 cycles of frozen embryos at the First Clinical College of Harbin Medical University Resuscitation transplantation, observation of the effect of frozen-thawed transplantation. Results 370 embryos, 316 surviving, 232 surviving embryos, 316 embryos transplanted and 39 clinical pregnancies were achieved. The pregnancy rate was 32.5% (39/120). Embryo implantation rate was 16.5% (52/316). There was no significant difference in age, estradiol level, endometrial thickness, survival rate of embryo resuscitation and complete survival between pregnant and non-pregnant group (P> 0.05), and there was significant difference in the rate of high-quality embryo (P <0.01). Conclusion High-quality embryos are the key to obtain pregnancy after transplantation. The frozen-thawed embryo transfer technique can increase the cumulative pregnancy rate of assisted reproductive technology.