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白细胞介素—2(IL—2)是重要的免疫调节因子,有报道表明使用IL—2可使肿瘤消退。但全身性静脉给予有效剂量的IL—2会产生一些严重的副作用。本文对局部应用IL—2的效果和副作用进行了研究。研究对象是5例(男4女1,65~76岁)患深部浸润性膀胱移行上皮细胞癌病人,属于T4G Ⅱ/Ⅲ期,无转移,未接受化疗和放疗。于不完全性经尿道切除术(TUR)后2~8天进行连续24小时的IL—2
Interleukin-2 (IL-2) is an important immunomodulatory factor and it has been reported that IL-2 can cause tumor regression. However, systemic intravenous administration of an effective dose of IL-2 will produce some serious side effects. This article studies the effect and side effects of topical application of IL-2. The subjects were 5 patients (male, 4 female 1, 65-76 years old) suffering from deep invasive bladder transitional cell carcinoma. They belonged to stage T4G II/III, had no metastasis, and had not received chemotherapy or radiotherapy. IL-2 for 24 hours after 2 to 8 days after incomplete transurethral resection (TUR)