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本实验用放射免疫法检测了140例正常人,动态测定了46例食管、贲门癌,40例非癌胸疾病人手术前、后血清胃泌素水平。结果表明:食管、贲门癌病人血清胃泌素水平明显升高,其程度与肿瘤病期、原发肿瘤大小、淋巴结转移,以及组织学类型有密切关系。本实验证明:(1)食管、贲门癌病人切除肿瘤后,其血清胃泌素水平逐渐降低,术后14天左右达正常水平;(2)术后14天胃泌素能恢复至正常者,预后良好,反之,则预后不良。由此,作者认为动态测定血清胃泌素可作为食管和贲门癌诊断、判断预后、监测复发转移的一项重要参考指标。
In this experiment, 140 cases of normal people were detected by radioimmunoassay, and 46 cases of esophageal and cardiac cancers were dynamically determined, and 40 cases of non-cancerous breast disease were measured before and after the operation. The results showed that the serum gastrin levels in patients with esophageal and cardiac cancers were significantly higher. The degree of the serum gastrin levels was closely related to the tumor stage, primary tumor size, lymph node metastasis, and histological type. This experiment shows that: (1) After removal of tumors from esophageal and cardiac cancer patients, their serum gastrin levels gradually decreased and reached normal levels around 14 days after surgery; (2) Gastrin can return to normal levels 14 days after operation. The prognosis is good; otherwise, the prognosis is poor. Thus, the authors believe that the dynamic determination of serum gastrin can be used as an important reference for the diagnosis of esophageal and cardiac cancer, prognosis, and monitoring of recurrence and metastasis.