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目的对石家庄市肺结核患者耐药情况进行分析,为控制石家庄市结核病疫情,制定肺结核病有效治疗方案提供依据。方法在2006—2007年石家庄市结核病防治所门诊就诊的405例涂阳肺结核病患者中,病灶面积>1个肺叶的256例肺结核病患者痰标本采用绝对浓度间接法,应用改良罗氏培养方法进行痰分枝杆菌培养、菌株鉴定和药敏试验。结果共培养出243株结核菌,人型结核菌185株、牛型52株、非典型分支杆菌6株;共有53株耐药,总体耐药率为21.81%;其中,原始耐药42株,继发耐药11株,耐药率分别为17.28%、4.53%;以耐链霉素(SM)、异烟胺(INH)为首。结论采取各种有效的方式、方法对广大民众进行结核病知识的宣传,特别是切实加强对流动人口的肺结核病患者的督导管理,使其做到服药规律、全程用药,是降低耐药菌发生的有效方法。
Objective To analyze the drug resistance of patients with pulmonary tuberculosis in Shijiazhuang City and provide basis for controlling the epidemic situation of tuberculosis in Shijiazhuang and formulating effective treatment programs for tuberculosis. Methods From 2006 to 2007, a total of 405 sputum smear positive pulmonary tuberculosis patients in outpatient TB clinic in Shijiazhuang City were enrolled. The sputum specimens of 256 pulmonary tuberculosis patients with lesions> 1 lung lobe were collected by sputum using absolute concentration indirect method and modified Roche culture method for sputum smear Mycobacterium culture, strain identification and drug sensitivity test. Results A total of 243 strains of Mycobacterium tuberculosis, 185 strains of Mycobacterium tuberculosis, 52 strains of cattle and 6 strains of atypical mycobacteria were screened out. A total of 53 strains were resistant with a total resistance rate of 21.81% 11 were resistant to secondary drug resistance rates were 17.28%, 4.53%; to streptomycin (SM), isoniazid (INH) headed. Conclusions Take various effective ways and methods to publicize the TB knowledge of the general population, especially to strengthen the supervision and management of tuberculosis patients in floating population so that they can take the law of taking medication and take full medication to reduce the occurrence of resistant bacteria Useful ways.