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头孢菌素是一类临床价值较高的抗生素。分子结构中均具有7-氨基头孢霉烷酸母核。其特点为抗菌谱广,杀菌作用强,对G~+和G~-菌、需氧菌或厌氧菌均有较强大的抗菌作用。对细菌所产生的β-内酰胺酶,较大多数半合成青霉素稳定;毒性低,副作用少,自六十年代临床应用以来,以其高效、广谱的特点,成为抗感染的重要选用药物,尤以第三代头孢菌素在临床上应用日益广泛。
Cephalosporins are a class of high clinical value of antibiotics. In the molecular structure of 7-aminocephalosporanic acid mother nucleus. It is characterized by broad antibacterial spectrum, strong bactericidal effect on G ~ + and G ~ - bacteria, aerobic bacteria or anaerobic bacteria have a more powerful antibacterial effect. The β-lactamase produced by bacteria is more stable than most semi-synthetic penicillins; it has low toxicity and few side effects. Since its clinical application in the 1960s, it has become an important anti-infective drug with its high efficiency and broad- Especially in the third generation of cephalosporins in the clinical application of an increasingly widespread.