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目的:总结近年来国内外前哨淋巴结活检术(SLNB)在早期宫颈癌中的应用进展。方法:应用PubMed及CNKI全文数据库,以前哨淋巴结、宫颈颈癌为关键词检索2000-01-2007-02相关宫颈癌前哨淋巴结的文献。文献纳入标准:1)影响前哨淋巴结的检出因素研究;2)前哨淋巴结识别方法的研究;3)前哨淋巴结活检术在早期宫颈癌研究。粗选有105篇的相关文献,根据纳入标准,纳入分析23篇文献。结果:前哨淋巴结是肿瘤细胞区域淋巴引流发生转移必经的第一站淋巴结。在早期宫颈癌研究中,可以代表盆腔淋巴结的转移状态。患者的临床病理特征、示踪剂、病理学检查方法是影响SLNB的主要因素。SLNB提高了早期宫颈癌保留生育功能手术的安全性。目前前哨淋巴结活检术在早期宫颈癌研究中显示此项技术的可行性及安全性。结论:研究前哨淋巴结活检术在早期宫颈癌中的应用具有重要意义,可以减少手术的并发症,提高微转移的检出率。
Objective: To summarize the application of sentinel lymph node biopsy (SLNB) at home and abroad in the early stage of cervical cancer. Methods: According to the literature of sentinel lymph node and cervical cancer, the PubMed and CNKI full-text databases were used to search for the sentinel lymph node of cervical cancer from January 2000 to February 2007. Literature inclusion criteria: 1) study of factors affecting the detection of sentinel lymph nodes; 2) study of SLN identification methods; and 3) SLN biopsy in early cervical cancer studies. Crude selection of 105 related articles, according to the inclusion criteria, included in the analysis of 23 articles. Results: The sentinel lymph node is the first lymph node that must pass through the lymphatic drainage in the tumor cell area. In early cervical cancer research, can represent the pelvic lymph node metastasis. The clinical and pathological characteristics of patients, tracer, pathological examination method is the main factor affecting SLNB. SLNB improves the safety of early cervical cancer-retained fertility surgery. Currently, sentinel lymph node biopsy shows the feasibility and safety of this technique in early cervical cancer research. Conclusion: The study of sentinel lymph node biopsy in early cervical cancer is of great significance, which can reduce the complications of surgery and improve the detection rate of micrometastasis.