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将取自新型隐球菌病65例的材料作新型隐球菌培养。其中,隐球菌性脑膜炎11例,播散性而无脑膜炎的隐球菌病11例,呼吸道隐球菌病43例。此外,还做了涂片及抗原检查。用二性霉素B治疗者,开始用1毫克,然后每天增加5毫克加入5％葡萄糖1,000毫升中静滴,直至1毫克/公斤/日为止。若出现肾毒性(血清肌酐浓度超过2毫克/100毫升),则减量或停药。合用5-氟胞嘧啶者,剂量150毫克/公斤,分4次口服,其二性霉素B用量不变。结果:11例平均年龄56.9岁(28～76岁)的新型隐球菌性脑膜炎患者,主要症状和体征是头痛(8例),运动失调(6例),进行性精神障碍、发热(各5例),颅神经瘫痪、颈硬(各3例),双侧巴氏征阳性(2例),恶心、呕吐(1例)和大便失禁
65 cases of new cryptococcosis material taken as Cryptococcus neoformans culture. Among them, 11 cases of cryptococcal meningitis, disseminated meningitis in 11 cases of cryptococcosis, respiratory tract cryptococcosis in 43 cases. In addition, smears and antigen tests were done. Treatment with amphotericin B began with 1 mg, followed by 5 mg daily addition of 5 ml dextrose in 1,000 ml intravenous drip until 1 mg / kg / day. In the event of nephrotoxicity (serum creatinine concentration exceeds 2 mg / 100 ml), the dose is reduced or discontinued. Combination of 5-fluorocytosine, a dose of 150 mg / kg, 4 times orally, the amount of amphotericin B unchanged. Results: Eleven cases of new cryptococcal meningitis with an average age of 56.9 years (28-76 years) had headache (8 cases), dyskinesia (6 cases), progressive mental disorders and fever ), Cranial nerve paralysis, cervical stiffness (3 in each case), positive bivalve symptoms (n = 2), nausea and vomiting (1) and fecal incontinence