采用生物粘合释药系统向不同表皮膜投药最近已引起重视。生物粘合制剂可向口腔、鼻眼、阴道或胃肠道(局部)释药,增加药物与表面的接触时间和接触密度以控制释药速度和吸收量。生物粘合(Bioadhesion)是指两种物质通过表面张力粘合一起,而其中至少一种为生物性物质。对释药体系而言,生物粘合是指合成的或生物性的大分子与亲水胶(Hydrocolloid)粘合于生物组织上。生物粘合性即指合成的或生物性的大分子,亲水胶与组织相互作用或粘合在一起的能力。一些粘合于口腔或消化道表面的细菌常引 The use of bioadhesive drug delivery systems to different epidermal membranes has recently attracted attention. Bioadhesive formulations can be delivered to the mouth, nose, eyes, vagina, or gastrointestinal tract (topically), increasing drug-to-surface contact time and contact density to control drug release rate and absorption. Bioadhesion means that two substances are bound together by surface tension and at least one of them is a biological substance. For drug delivery systems, bioadhesion refers to the binding of synthetic or biological macromolecules to a biological tissue with a Hydrocolloid. Bioadhesion refers to the ability of synthetic or biological macromolecules, hydrophilic glue, to interact with or bind to tissue. Some bacteria stick to the mouth or digestive tract often cited