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目的监测云南省一类疟区人群的间日疟原虫抗体(Ig G)水平,为云南省消除疟疾行动的流行预测和防控效果评价提供科学依据。方法 2013—2014年在云南6个一类疟区县(市)采用分层随机抽样采集居民滤纸血膜,采用ELISA试剂盒检测间日疟原虫特异性抗体,采用SPSS 20.0统计软件进行抗体阳性率及抗体滴度检验,变量间相关性进行Pearson分析。结果共检测腾冲、盈江、耿马、瑞丽、孟连、盐津6县(市)的7 050份血样,间日疟原虫抗体(Ig G)阳性率为9.05%,各县间抗体阳性率差异有统计学意义(P<0.05),且5个边境县的平均抗体阳性率显著高于内地县盐津的阳性率,差异有统计学意义(P<0.05);女性的阳性率9.98%显著高于男性7.95%,差异有统计学意义(P<0.05);学生的阳性率10.79%显著高于居民7.74%,差异有统计学意义(P<0.05);少年儿童、青壮年和中老年组的阳性率分别为9.52%、7.59%和9.40%,各组间差异无统计学意义(P>0.05);全省合计及6个县(市)2013年和2014年的抗体阳性率差异均无统计学意义(P>0.05)。结论云南省一类疟区的人群间日疟原虫抗体(lg G)水平能反映前期的疟疾流行强度,女性、学生人群间日疟原虫抗体水平高的现象值得重视。
Objective To monitor the level of IgM in malaria endemic areas of Yunnan Province and provide a scientific basis for the epidemic prediction and prevention and control of malaria elimination in Yunnan Province. Methods Blood samples were collected from 6 filter-beds of malaria-endemic counties in Yunnan Province by stratified random sampling from 2013 to 2014. ELISA kit was used to detect the specific antibodies against Plasmodium vivax, and the antibody positive rate was detected by SPSS 20.0 software And antibody titer test, the correlation between variables Pearson analysis. Results 7 050 blood samples of Tengchong, Yingjiang, Gengma, Ruili, Menglian and Yanjin were detected. The positive rate of IgM was 9.05% (P <0.05). The average antibody positive rate in five border counties was significantly higher than that of Yanjin in the inland counties (P <0.05), and the positive rate of 9.98% in women was significantly higher (P <0.05). The positive rate of students was significantly higher than that of residents (7.74%) (P <0.05), and the difference was statistically significant (P <0.05). Children, young and middle-aged and elderly (9.52%, 7.59% and 9.40% respectively). There was no significant difference among the three groups (P> 0.05). There was no difference in the positive rate of antibody between 2013 and 2014 in the whole province and in 6 counties Statistical significance (P> 0.05). Conclusions The level of IgM in the population of first-rate malaria endemic areas in Yunnan Province can reflect the strength of the malaria epidemic in the early stage. The phenomenon of high level of anti-Plasmodium vivax in female and student populations deserves attention.