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目的评价江西省艾滋病患者接受艾滋病抗病毒治疗前后的疗效,为该地区艾滋病防治提供依据。方法采用整群抽样方法,于2009年7月抽取261例患者,从血象与生化指标上分析抗病毒治疗效果。结果艾滋病患者治疗前后的白细胞、红细胞、血小板、血红蛋白、淋巴细胞绝对值的血象异常率有明显提高(P<0.05),治疗前后的总蛋白、清蛋白、直接胆红素异常率有明显下降(P<0.05),治疗前后的CD4、丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰转肽酶、总胆红素、间接胆红素、血糖、总胆固醇、甘油三酯、尿素氮、肌酐的异常率差异均无统计学意义(P>0.05)。计量结果提示治疗前后CD4、ALT、总蛋白、清蛋白方面的疗效有明显好转(P<0.05)。结论抗病毒治疗疗效在一定程度上较为明显,但多数指标还难以达到正常值水平,因人而异的对症治疗显得尤其必要。
Objective To evaluate the efficacy of HIV / AIDS patients before and after treatment in AIDS prevention and treatment in Jiangxi Province and provide the basis for AIDS prevention and control in this area. Methods A total of 261 patients were enrolled in July 2009 by cluster sampling method. The effects of antiviral therapy were analyzed from the blood and biochemical parameters. Results The abnormal rate of leucocyte, erythrocyte, platelet, hemoglobin and lymphocyte absolute value before and after treatment in AIDS patients was significantly higher (P <0.05), and the total protein, albumin and direct bilirubin were significantly decreased before and after treatment (P <0.05), CD4, alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyl transpeptidase, total bilirubin, indirect bilirubin, blood glucose, total cholesterol , Triglyceride, urea nitrogen, creatinine were no significant difference (P> 0.05). Measurement results suggest that before and after treatment, CD4, ALT, total protein, albumin efficacy was significantly improved (P <0.05). Conclusion The efficacy of antiviral therapy is more obvious to a certain extent, but most of the indicators are still difficult to reach the normal level, and symptomatic treatment varies from person to person.