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目的:分析讨论乙肝免疫球蛋白联合乙肝疫苗应用在阻断乙型肝炎病毒(HBV)母婴垂直传播中的临床效果。方法:本组选择2014年1月~2016年1月我院收治治疗的84例乙型肝炎病毒表面抗原(HBsAg)携带者母亲的婴儿作为研究对象,采取随机双盲法将其分为对照组以及试验组,每组42例,其中对照组选择单用乙肝疫苗方法,试验组选择乙肝免疫球蛋白联合乙肝疫苗方法。结果:试验组患者的慢性HBV感染率及初现HBsAg阳性率情况明显的低于对照组,2组患者的慢性HBV感染率及初现HBsAg阳性率情况差异具有统计学意义(P<0.05)。结论:乙肝免疫球蛋白联合乙肝疫苗可显著提升母婴垂直传播的阻断效果,降低乙型肝炎病毒的感染率,切可以有效的减少初现乙型肝炎病毒表面抗原阳性婴儿的慢性化,在临床中值得广泛的关注与推广。
Objective: To analyze and discuss the clinical effect of hepatitis B immunoglobulin combined with hepatitis B vaccine in blocking the vertical transmission of hepatitis B virus (HBV) between mother and infant. Methods: A total of 84 infants with HBsAg carriers from January 2014 to January 2016 were enrolled in this study. Patients were divided into control group And the experimental group, 42 cases in each group, of which the control group chose to use hepatitis B vaccine alone, the experimental group chose hepatitis B immunoglobulin combined with hepatitis B vaccine. Results: The incidence of chronic HBV infection and HBsAg positive rate in the experimental group was significantly lower than that in the control group. There was significant difference between the two groups in chronic HBV infection and HBsAg positive rate (P <0.05). Conclusion: Hepatitis B immunoglobulin combined with hepatitis B vaccine can significantly improve the blocking effect of vertical transmission of mother and baby, reduce the infection rate of hepatitis B virus, and can effectively reduce the appearance of chronic hepatitis B virus surface antigen-positive infants Clinic worth a wide range of attention and promotion.