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1971年DiRosa首先建立了角叉菜诱发的大鼠胸膜炎模型(非免疫性炎症模型),之后,因已知细胞免疫、免疫复合物所介导的反应在各种风湿性疾病,尤其是类风湿性关节炎的病理过程中起着主导作用,人们开始试图复制与人类疾病更为相近的动物胸膜炎模型。1975年Yamamoto等报道了大鼠Arthus反应性胸膜炎,另外两种迟发型变态反应性胸膜炎模型亦相继报道,并被广泛地应用于抗炎抗风湿药物的研究。利用这类炎症模型,人们可精确地、定性定量地观测药物对炎症
DiRosa first established a carrageenan-induced rat pleurisy model (a non-immune inflammatory model) in 1971, after which, due to cellular immunity known, immune-complex-mediated responses have been widely observed in various rheumatic diseases, especially rheumatoid Arthritis plays a leading role in the pathological process and people are trying to replicate animal pleurisy models that are more similar to human disease. In 1975, Yamamoto et al reported rat Arthus reactive pleurisy, and the other two delayed-type allergic pleurisy models were also reported one after another, and are widely used in the study of anti-inflammatory and antirheumatic drugs. With this type of inflammation model, one can observe drugs accurately, qualitatively and quantitatively against inflammation