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目的:探讨卵巢储备功能下降(DOR)患者体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)的临床妊娠率与年龄的关系。方法:回顾性分析DOR患者行IVF-ET微刺激治疗方案的患者资料,按照患者年龄分为3组:A组(<35岁,n=105),B组(35~38岁,n=114),C组(>38岁,n=173),比较分析不同年龄组患者一般情况及妊娠结局。结果:各组患者的基础FSH、基础LH、基础E_2、基础窦卵泡数(AFC)、平均每日促性腺激素(Gn)用量、平均Gn使用天数、平均Gn使用总量均无统计学差异(P>0.05),促排卵后获卵数、正常受精数、可用胚胎数、优质胚胎数、扳机日LH水平、扳机日E_2水平、未获可移植胚胎率、可移植周期平均移植次数均无统计学差异(P>0.05),但生化妊娠率、临床妊娠率、种植率均随着年龄的增加呈下降趋势,A、B组的生化妊娠率、临床妊娠率、种植率与C组相比有着显著的统计学差异(P<0.05,P<0.01)。结论:DOR患者的生化妊娠率、临床妊娠率、种植率随年龄的增加而下降,年轻的DOR不孕患者临床妊娠结局相对较好。
Objective: To investigate the relationship between clinical pregnancy rate and age in in vitro fertilization and embryo transfer (IVF-ET) in patients with ovarian reserve degeneration (DOR). Methods: The data of patients undergoing IVF-ET in patients with DOR were retrospectively analyzed. Patients were divided into three groups according to their age: group A (n = 35, n = 105), group B ), Group C (> 38 years old, n = 173). The general situation and pregnancy outcome in different age groups were analyzed. Results: The basal FSH, basal LH, basal E_2, basal antral follicle count (AFC), average daily gonadotrophin (Gn) dosage, mean days of Gn usage and average Gn usage were not significantly different among all groups P> 0.05). The number of oocytes retrieved after ovulation, the number of normal fertilization, the number of available embryos, the number of high quality embryos, the level of triggering LH, the level of triggering E_2, the rate of non-transferable embryos and the mean number of transplantable cycles were all not statistically significant (P> 0.05). However, the biochemical pregnancy rate, clinical pregnancy rate and implantation rate all decreased with the increase of age. The biochemical pregnancy rate, clinical pregnancy rate and implantation rate in groups A and B were significantly higher than those in group C Significant statistical difference (P <0.05, P <0.01). Conclusion: The biochemical pregnancy rate, clinical pregnancy rate and implantation rate of DOR patients decline with age. The clinical pregnancy outcome of young DOR infertility patients is relatively good.