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从四川产轮环藤(防己科Cyclea racemosa Oliv)根中获得一种新的双苄基异喹啉(BBI)生物碱,命名轮环藤新碱(cycleaneonine)。通过质谱和几种光谱鉴定分析,证明分子中具有一个对-二甲苯基部份,结构如(Ⅰ)。这种基核结构的BBI生物碱是首次从Cyclea属植物中获得。初步药理试验表明,轮环藤新碱具有显著的抗癌活性。
A new bis-benzylisoquinoline (BBI) alkaloid was obtained from the root of Cyclea racemosa Oliv. from Sichuan, named cycleaneonine. Through mass spectrometry and several spectral identification analyses, it was demonstrated that the molecule has a p-xylyl moiety with a structure such as (I). This basic nuclear structure of BBI alkaloids was obtained from the genus Cyclea for the first time. Preliminary pharmacological tests have shown that rotenedine has significant anticancer activity.