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目的探讨分析卡培他滨联合三维适形放疗在老年中晚期食管癌治疗中的临床疗效及安全性。方法 92例老年中晚期食管癌患者,采用随机数字表法分为研究组(45例)与对照组(47例)。两组患者均采取三维适形放疗。同时,对照组采取洛铂化疗,研究组患者给予卡培他滨化疗。比较两种方案临床疗效。结果研究组完全缓解(CR)19例,部分缓解(PR)24例,有效率为95.6%(43/45)。对照组CR 15例,PR 20例,有效率为74.5%(35/47)。研究组有效率优于对照组(P<0.05)。治疗期间两组患者毒副反应发生率比较差异无统计学意义(P>0.05)。随访1年,研究组患者生存率高于对照组(P<0.05)。结论卡培他滨联合三维适形放疗可提高老年中晚期食管癌临床疗效,延长患者生存期,且安全性较好。
Objective To investigate the clinical efficacy and safety of capecitabine combined with three-dimensional conformal radiotherapy in the treatment of elderly patients with advanced esophageal cancer. Methods 92 elderly patients with advanced esophageal cancer were divided into study group (n = 45) and control group (n = 47) by random number table. Two groups of patients were taken three-dimensional conformal radiotherapy. At the same time, the control group took lobaplatin chemotherapy and the study group received capecitabine chemotherapy. Compare the clinical efficacy of the two programs. Results The study group had complete remission (CR) in 19 cases and partial remission (PR) in 24 cases. The effective rate was 95.6% (43/45). The control group CR 15 cases, PR 20 cases, the effective rate was 74.5% (35/47). The study group was better than the control group (P <0.05). There was no significant difference in the incidence of side effects between the two groups during treatment (P> 0.05). The follow-up of 1 year, study group patients survival rate was higher than the control group (P <0.05). Conclusion Capecitabine combined with three-dimensional conformal radiotherapy can improve the clinical efficacy of advanced esophageal cancer in elderly patients, prolong the survival of patients with good safety.