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目的 了解雌三醇栓阴道给药对老年性阴道炎的临床治疗效果。方法 对45例绝经后患老年性阴道炎的妇女随机分成两组:治疗组,每日用含2mg 雌三醇的阴道用栓剂放入阴道,一周后每周放入一枚,连用8周;对照组,每日用0.5克倍美为软膏(含倍美力0.3125mg)于阴道内,一周后每周用药一次,连用8周。于用药前,用药后第 7、28、56天进行阴道健康评分及阴道细胞成熟指数测定,用药前及用药结束后进行改良 Kupperman评分,血清激素、血脂及肝肾功能测定。结果 治疗组和对照组用药后,围绝经期症侯群显著改善,Kupperman 评分分别由18.8±8.38分和19.93±5.95分下降至3.23±3.36和2.33±2.77分(P<0.05)。外阴阴道症状明显改善,治疗组的阴道健康评分由治疗前的10分上升到23分,对照组由11分上升至22分,治疗前后差异显著(P<0.05)。血清雌二醇水平明显上升至卵泡早期水平,治疗组由用药前的 12.08±5.87ng/L上升至 33.63±4.83ng/L,对照组由用药前的15.78±8.38ng/L上升至 33.05±0.28ng/L,两组治疗前后差异显著(P<0.05)。伴随阴道症状和围经绝期症状改善同时,两组均使总胆固醇(TC)下降,甘油三酯(TG),低密度脂蛋白(LDL)上升,但差异均无统计学显著意义(P>0.05),治疗组用药后HDL、HDL/LDL 比值显著上升(P<0.05)。结论 与国内外已广泛使
Objective To investigate the clinical effect of vaginal administration of estriol suppository on senile vaginitis. Methods Forty-five women with senile vaginitis after menopause were randomly divided into two groups: treatment group, vaginal suppository with 2 mg estriol daily, one week after one week for 8 weeks, control group Group, daily with 0.5 grams times as the United States for the ointment (containing Betamel 0.3125mg) in the vagina, a week after a medication, once every 8 weeks. Vaginal health score and vaginal cell maturation index were measured before treatment, 7th, 28th, and 56th day after treatment. The Kupperman score, serum hormone, blood lipid and liver and kidney function were measured before treatment and after treatment. Results After the treatment group and the control group, the climacteric syndrome group was significantly improved, Kupperman score decreased from 18.8 ± 8.38 and 19.93 ± 5.95 points to 3.23 ± 3.36 and 2.33 ± 2.77 points (P <0.05). Vulvovaginal symptoms were significantly improved. The score of vaginal health in the treatment group increased from 10 to 23 before treatment and from 11 to 22 in the control group. The difference was significant (P <0.05) before and after treatment. Serum estradiol levels rose significantly to early follicle levels in the treatment group from 12.08 ± 5.87ng / L before treatment to 33.63 ± 4.83ng / L in the control group from 15.78 ± 8.38ng / L before treatment to 33.05 ± 0.28 ng / L, there was significant difference between the two groups before and after treatment (P <0.05). With the improvement of vaginal symptoms and perimenopausal symptom, the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) increased in both groups, but the differences were not statistically significant (P> 0.05). After treatment, HDL and HDL / LDL ratio increased significantly (P <0.05). Conclusions have been widely used both at home and abroad