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t(11;18 ) (q2 1;q2 1)和t(1;14 ) (p2 2 ;q32 )是在胃MALT淋巴瘤中发生率较高和研究较多的染色体异常 ,前者产生新的融合蛋白 ,后者使Bcl 10蛋白在核内过度表达。两类看似并无关联的染色体异常导致同样的最终结果 ,即通过蛋白特定区域的寡聚化作用激活NF кB通路 ,使下游多种与细胞增殖和分化相关的基因表达失调控 ,并由此引发细胞的恶性转化。
T (11; 18) (q2 1; q2 1) and t (1; 14) (p2 2; q32) are chromosomal abnormalities with a high prevalence and more studied in gastric MALT lymphoma, the former producing a new fusion Protein, which overexpresses the Bcl10 protein in the nucleus. Two seemingly unrelated chromosomal abnormalities lead to the same end result: activation of the NF кB pathway by oligomerisation of specific regions of the protein, downregulation of a variety of downstream genes associated with cell proliferation and differentiation, and thus Lead to malignant transformation of cells.