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目的：评价国产氟西汀的抗抑郁作用及安全性。方法：采用随机、双盲对照、多中心研究，分为国产氟西汀组５７例（男性２２例，女性３５例；年龄４０±ｓ１３ａ），口服氟西汀２０ｍｇ，ｑｄ，阿米替林５７例（男性２７例，女性３０例；年龄４０±１４ａ），口服阿米替林７５ｍｇ，ｂｉｄ，疗程６ｗｋ。结果：氟西汀治疗抑郁障碍的疗效与阿米替林相当，总有效率分别为８５％及９２％（Ｐ＞０．０５）；氟西汀组的主要副作用有口干、便秘、恶心、心动过速等，但较之阿米替林程度轻且发生率低。结论：氟西汀的抗抑郁作用与阿米替林相当，副作用少，服用方便。
Objective: To evaluate the antidepressant effect and safety of domestic fluoxetine. Methods: A randomized, double-blind, multicenter study was conducted in 57 Chinese-made fluoxetine-containing patients (22 males and 35 females; age 40 ± s13a), oral fluoxetine 20 mg, qd, amitriptyline 57 Cases (27 males, 30 females; age 40 ± 14a), oral amitriptyline 75mg, bid, treatment 6wk. Results: The efficacy of fluoxetine in the treatment of depression was comparable to amitriptyline, and the total effective rate was 85% and 92% respectively (P> 0.05). The main side effects of fluoxetine were dry mouth, constipation, nausea, Tachycardia, etc., but the degree of light than the amitriptyline and the incidence is low. Conclusion: The antidepressant effect of fluoxetine is comparable to that of amitriptyline, with fewer side effects and easy to take.