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目的探讨PCNA、P53r、asP21与肺癌临床病理特征的关系及联合表达的意义。方法应用免疫组化S-P法检测了81例肺癌组织(鳞癌46例、腺癌35例)、20例正常肺组织中PCNA、P53r、asP21的表达情况。结果PCNA、P53、ras-P21在肺癌组织中分别表达67%、54%、56%,而在正常肺组织中的阳性表达率分别为5%、5%、0%。结论PCNA、P53、rasP21对肺癌发生、发展有密切关系,如果能排除肿瘤类型、分期、淋巴结转移等因素的相互干扰,其准确性可能会进一步提高。
Objective To investigate the relationship between the expression of PCNA, P53r, asP21 and the clinicopathological features of lung cancer and their significance. Methods The expression of PCNA, P53r and asP21 in 81 cases of lung cancer (46 cases of squamous cell carcinoma, 35 cases of adenocarcinoma) and 20 cases of normal lung tissue were detected by immunohistochemical S-P method. Results The positive rates of PCNA, P53 and ras-P21 in lung cancer tissues were 67%, 54% and 56%, respectively. The positive expression rates in normal lung tissues were 5%, 5% and 0% respectively. Conclusion PCNA, P53 and rasP21 are closely related to the occurrence and development of lung cancer. The accuracy of PCNA, P53 and rasP21 may be further improved if they can exclude the interference of tumor type, stage and lymph node metastasis.