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目的探讨液基细胞学检查配合阴道镜在宫颈疾病筛查中的价值及意义。方法纳入2014年1月—2015年12月在我院妇科进行治疗的980例妇女为研究对象,将其进行阴道镜与液基细胞学,并将检查结果与病理检查结果进行比较,并评价不同年龄段妇女的疾病的分布状况。结果病理检查共检出75例宫颈病变患者,其中原位癌、宫颈上皮内瘤变(CIN)Ⅰ、Ⅱ、Ⅲ分别为3、17、6、7例。阴道镜诊断灵敏度:75.00%(12/16),特异度:93.22%(55/59),阳性预测值:75.00%(12/16),阴性预测值:93.22%(55/59)。液基细胞学配合阴道镜检查灵敏度:87.50%(14/16),特异度:98.30%(58/59),阳性预测值:87.50%(14/16),阴性预测值:98.31%(58/59)。液基细胞学配合阴道镜检查灵敏度:87.50%(14/16),特异度:98.30%(58/59),阳性预测值:87.50%(14/16),阴性预测值:98.31%(58/59)。40岁及以下患者的低度及以下病变比例显著高于40岁以上患者(P<0.05),40岁以上患者的低度以上病变比例显著高于40岁及以下患者(P<0.05),50岁以上患者原位癌的发病率显著高于50岁及以下患者(<0.05)。结论液基细胞学配合阴道镜检查筛查宫颈疾病方法临床价值高,40岁以上人群的宫颈病变发生率较高。
Objective To investigate the value and significance of liquid-based cytology and colposcopy in cervical disease screening. Methods One hundred and eighty-eight women who underwent gynecology in our hospital from January 2014 to December 2015 were enrolled in this study. Colposcopy and liquid-based cytology were performed. The results were compared with the results of pathological examination and evaluated The distribution of disease among women in the age group. Results A total of 75 cases of cervical lesions were detected by pathological examination. The in situ carcinoma and cervical intraepithelial neoplasia (CIN) Ⅰ, Ⅱ and Ⅲ were 3,17,6,7 cases respectively. Colposcopy diagnostic sensitivity: 75.00% (12/16), specificity: 93.22% (55/59), positive predictive value: 75.00% (12/16), negative predictive value: 93.22% (55/59). The sensitivity of liquid-based cytology with colposcopy was 87.50% (14/16), the specificity was 98.30% (58/59), the positive predictive value was 87.50% (14/16) and the negative predictive value was 98.31% (58 / 59). The sensitivity of liquid-based cytology with colposcopy was 87.50% (14/16), the specificity was 98.30% (58/59), the positive predictive value was 87.50% (14/16) and the negative predictive value was 98.31% (58 / 59). The proportion of low and lower lesions in patients 40 years and younger was significantly higher than those in patients over 40 years old (P <0.05). The incidence of low-grade lesions was significantly higher in patients over 40 years old than in those under 40 years old (P <0.05) The incidence of carcinoma in situ was significantly higher in patients over the age of 50 years (P <0.05). Conclusion Liquid-based cytology combined with colposcopy screening of cervical disease is of high clinical value, and the incidence of cervical lesions in people over 40 years old is higher.