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目的 检测血管炎患者sICAM 1、sVCAM 1、TNF α、TNFR Ⅰ、TNFR Ⅱ的血清水平并探讨其临床意义。方法 用ELISA法检测TNF α、TNFR Ⅰ、TNFR Ⅱ、sICAM 1、sVCAM 1的血清水平 ,并进行血管炎与对照组之间的两两比较。结果 39例血管炎患者与对照组相比 ,TNF α水平降低 ,TNFR Ⅰ、sICAM 1、sVCAM 1水平升高 ,TNFR Ⅱ差异无显著性。结论 TNF α在本研究血管炎患者的发病中可能不起主要作用 ,其血清中的低水平也可能是因为其生物学作用被sTNFR中和所致 ;sICAM 1和sVCAM 1在血管炎的发病中起重要作用。
Objective To detect the serum levels of sICAM 1, sVCAM 1, TNFα, TNFR Ⅰ and TNFR Ⅱ in patients with vasculitis and to explore its clinical significance. Methods The serum levels of TNFα, TNFR Ⅰ, TNFR Ⅱ, sICAM 1 and sVCAM 1 were detected by ELISA. The pairwise comparisons between vasculitides and control groups were performed. Results Compared with the control group, the levels of TNFα, the levels of TNFR Ⅰ, sICAM 1 and sVCAM 1 were increased in 39 patients with vasculitis, but there was no significant difference in TNFR Ⅱ. Conclusions TNFα may not play a major role in the pathogenesis of vasculitis in this study. The low serum level may also be due to the biological role of TNFα being neutralized by sTNFR. In the pathogenesis of vasculitis, sICAM 1 and sVCAM 1 makes an important impact.