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TIMPs是一组多功能因子家族,能特异的抑制MMPs的活性。生理条件下产生的TIMPs对正常ECM的改建和组织器官的生理功能的维持具有重要作用。在病理条件下,作为MMPs的抑制剂则抑制肿瘤的侵袭和转移、启动和加重肝纤维化;同时不依赖其MMPs抑制活性对细胞生长、增殖和分化发挥重要作用,而作为VEGF生成的刺激因子则促进肿瘤的生长和转移。提示通过调节其基因表达和活性,在人类相关疾病的治疗中将会有更广泛的应用前景。
TIMPs are a family of multifunctional factors that specifically inhibit the activity of MMPs. TIMPs produced under physiological conditions play an important role in the remodeling of normal ECM and the maintenance of physiological functions of tissues and organs. Under pathological conditions, as inhibitors of MMPs, they inhibit tumor invasion and metastasis, initiate and aggravate liver fibrosis, and play an important role in cell growth, proliferation and differentiation independent of their MMPs inhibitory activity, and act as stimulators of VEGF production Promote tumor growth and metastasis. Prompted by regulating its gene expression and activity, in the treatment of human diseases will have a broader application prospects.