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肛管癌由于解剖特点,作彻底手术有一定困难,为了提高疗效,需要综合治疗。术前放疗加化疗是有价值的。因为鳞癌一般对治疗敏感,有效。作者介绍19例肛管癌,均经话检证实,包括侵及齿状线,除4例外病变均<5 cmφ。无腹股沟淋巴结转移,无远地转移,化疗与放疗同时应用,5氟脲嘧啶100毫克/平方米/天,连续静脉滴入,共4天,丝裂霉素15毫克/平方米/静脉注射,一次。一月后重复5氟嘧啶,放疗与化疗同时开始,中线量3000rad/3周(200rad/日)照射野15×15平方厘米,下缘包括坐骨结节,效疗完成后4～6周手术。
Anal canal cancer has certain difficulties for thorough surgery because of its anatomical characteristics. In order to improve the efficacy, comprehensive treatment is needed. Preoperative radiotherapy and chemotherapy are valuable. Because squamous cell carcinoma is generally sensitive to treatment, it is effective. The authors introduced 19 cases of anal canal cancer, were confirmed by the examination, including invasion of the dentate line, except for 4 exceptions were <5 cm φ. No inguinal lymph node metastasis, no distant metastasis, simultaneous application of chemotherapy and radiotherapy, 5 fluorouracil 100 mg/m 2 /day, continuous intravenous infusion for 4 days, mitomycin 15 mg/m 2 /intravenous injection, once. After one month, 5 fluoropyrimidine was repeated, radiotherapy and chemotherapy were started at the same time. The midline dose was 3000rad/3 weeks (200rad/day). The radiation field was 15×15cm2. The lower edge included the ischial tuberosity, and 4 to 6 weeks after the completion of the therapy.