作者报告了5例长期用苯妥英钠治疗的癫癎病人发生了小脑变性.5例病人均有高血浆浓度的苯妥英钠,而且在发生小脑综合征时均无可以引起全身性缺氧的癫癎发作形式.小脑变性是通过以下两方面确诊的:(1)CT扫描可见弥漫性小脑萎缩征象;(2)当苯妥英钠的血浆浓度降低时仍有持久性的 The authors reported cerebellar degeneration in five long-term epilepsy patients treated with phenytoin, all of which had high plasma concentrations of phenytoin sodium and no epileptic seizures that could cause systemic hypoxia in the presence of cerebellar syndrome Form. Cerebellar degeneration is diagnosed by (1) diffuse signs of cerebellar atrophy on the CT scan, (2) persistence of plasma phenytoin