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目的通过三拗片和二羟丙茶碱的抗炎、抗过敏、止咳、祛痰、扩张支气管作用、抑制气道炎症反应和降低气道高反应性,探讨两药联合应用治疗气道高反应性咳嗽症状控制的疗效。方法将我院2011年6月～2013年10月呼吸科门诊治疗的150例咳嗽患者为研究对象。依照随机对照原则将150例患者分为3组:对照组50例,治疗组50例,联合治疗组50例,三组患者的性别、年龄、病情严重程度及病程等一般资料经统计学处理无显著性差异,具有可比性。对比分析观察三组患者的临床治疗效果。结果在治疗第3天时,治疗组与联合治疗组比较差异无统计学意义。治疗第7天,联合治疗组与治疗组比较差异亦具有统计学意义,即治疗组咳嗽评分低于对照组,联合治疗组咳嗽评分低于治疗组,实验结果提示三拗片联合二羟丙茶碱使用,患者咳嗽症状能得到更好地控制,总有效率达88%。结论三拗片和二羟丙茶碱联合治疗气道高反应性咳嗽未见明显毒副作用,且价格低廉,值得临床推荐应用。
OBJECTIVE To study the anti-inflammatory, anti-allergic, antitussive, expectorant and bronchiolar effects of Sanwei tablet and dipyridamole, to inhibit airway inflammation and reduce airway hyperresponsiveness, and to explore the combination of two drugs in the treatment of airway hyperresponsiveness Cough symptoms control the curative effect. Methods A total of 150 cough patients undergoing respiratory clinics in our hospital from June 2011 to October 2013 were enrolled in this study. According to the principle of randomized control, 150 patients were divided into three groups: control group, 50 cases, treatment group, 50 cases, combined treatment group, general information on gender, age, severity of disease and course of disease were statistically Significant differences, comparable. Comparative analysis of three groups of patients observed the clinical effect. Results At the third day of treatment, there was no significant difference between the treatment group and the combination therapy group. On the 7th day of treatment, the difference between the combination therapy group and the treatment group was also statistically significant, that is, the cough score of the treatment group was lower than that of the control group, and the cough score of the combination therapy group was lower than that of the treatment group. The use of alkali, the patient’s cough symptoms can be better controlled, the total effective rate of 88%. Conclusion Sandwiched and diprophylline combined treatment of airway hyperresponsive cough no obvious side effects, and the price is low, it is clinically recommended.