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目的 :探讨糖尿病肾病 ( DN)临床中尿白蛋白排泄率 ( UAER)与组织纤溶酶原激活物 ( t- PAA)、纤溶酶原激活物抑制物 ( PAIA )的相关性。方法 :对 71例糖尿病患者和 30例正常人的 U AER和 t- PAA、PAIA进行测定 ,并对其相关性进行统计分析。结果 :糖尿病组 t- PAA随着 UAER的增高而降低 ,而 PAIA则随着 UAER的增高而增高 ,糖尿病微量白蛋白尿组、临床蛋白尿组 t- PAA与 U AER呈显著负相关 ( P <0 .0 1) ,PAIA与 U AER呈显著正相关 ( P<0 .0 1)。结论 :糖尿病肾病早期即有纤溶活性低下。t- PAA和 PAIA测定可作为糖尿病肾病早期诊断和病情进展的检测指标
Objective: To investigate the correlation between urinary albumin excretion rate (UAER) and tissue plasminogen activator (t-PAA) and plasminogen activator inhibitor (PAIA) in patients with diabetic nephropathy (DN). Methods: UAER, t-PAA and PAIA in 71 patients with diabetes mellitus and 30 normal subjects were measured and their correlations were statistically analyzed. Results: The t-PAA in diabetes mellitus decreased with the increase of UAER, while the PAIA increased with the increase of UAER. There was a significant negative correlation between t-PAA and UAER in diabetic microalbuminuria group and clinical proteinuria group (P < 0 .0 1), there was a significant positive correlation between PAIA and U AER (P <0.01). Conclusion: Early diabetic nephropathy is fibrinolytic activity is low. t-PAA and PAIA assay can be used as indicators of early diagnosis and progression of diabetic nephropathy