目的为了解儿童急性淋巴细胞白血病医院感染状况。方法对某医院４年内收治的急性淋巴细胞白血病患儿共７８例进行回顾性调查。结果发生医院感染的共２７例，占同期住院儿童急性淋巴细胞白血病患儿的３４．６２％。感染的病原菌主要是Ｇ－杆菌和真菌，感染部位以皮肤及软组及上呼吸道最常见。白细胞减少、化疗是增加感染的危险因素。结论提示医院感染的发生与白血病患儿免疫功能低下有关。 Objective To understand the status of nosocomial infection in children with acute lymphoblastic leukemia. Methods A total of 78 children with acute lymphoblastic leukemia admitted to a hospital within 4 years were retrospectively reviewed. Results A total of 27 cases of nosocomial infections occurred, accounting for 34.62% of children hospitalized with acute lymphoblastic leukemia in the same period. Infected pathogens are mainly G-bacteria and fungi, the most common site of infection to the skin and soft tissue and the upper respiratory tract. Leukopenia, chemotherapy is to increase the risk of infection. Conclusions suggest that the occurrence of nosocomial infections and leukemia in children with immune dysfunction.