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目的探讨慢性心力衰竭(CHF)患者血清CA125水平的变化及其临床意义。方法分别对CHF组、非CHF组和健康对照组抽取晨血5 ml做血清CA125水平检测,同时检测肿瘤两项(CEA、AFP),摄X线胸片,以及腹部、盆腔超声等检查,排除潜在的肿瘤、胸腔或心包积液,然后进行统计学分析。结果与非CHF组和健康对照组比较,CHF组血清CA125水平显著升高,且与心力衰竭严重程度(Ⅱ、Ⅲ、Ⅳ级)相关(分别P<0.05、<0.01、<0.001)。结论在CHF时CA125水平升高,并与心力衰竭严重程度明显相关,CA125是否能作为诊断和评价CHF的简易指标,值得进一步研究。
Objective To investigate the changes of serum CA125 level in patients with chronic heart failure (CHF) and its clinical significance. Methods The levels of serum CA125 in CHF group, non-CHF group and healthy control group were determined. Serum levels of CA125 were detected at the same time. Two tumors (CEA, AFP), X-ray, and abdominal and pelvic ultrasound examination were performed. Potential tumor, pleural or pericardial effusion was followed by statistical analysis. Results Compared with non-CHF group and healthy control group, serum CA125 level in CHF group was significantly higher than that in CHF group (P <0.05, <0.01, <0.001, respectively). Conclusions The level of CA125 is elevated in CHF and is significantly correlated with the severity of heart failure. Whether CA125 can be used as a simple index for the diagnosis and evaluation of CHF deserves further study.